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KMID : 0381920100400030139
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Korean Journal of Microscopy
2010 Volume.40 No. 3 p.139 ~ p.145
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A Study of Effectiveness of Lithospermum erythrorhizon Extracts on the Skin by UVB-Irradiation C57BL/6 Mouse
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Lee Hyun-Hwa
Song Seon-Young
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Abstract
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This study was intended to identify the effectiveness of Lithospermum erythrorhizon in the UVB-damaged mouse skin. The C57BL/6 mouse that weighted about 18 g were divided into three groups; the control group (A group), the UVB irradiated group (B group), and the group treated with Lithospermum erythrorhizon extracts after UVB irradiation (C group). In the results of superoxidase dismutant(SOD) activities, the C group was meaningfully lower at the 48hrs, 120 hrs, and 168 hrs group than B group (p?0.05). In the result of catalase(CAT) activities, the C group was decreased at the 120 hrs and 168 hrs group, but meaningless (p¤0.05). In the result of light micrograph observation, the B group observed sunburn cells in the epidermis and acute inflammation in the dermis at the 24 hrs and 48 hrs. And proliferation of the epidermis and the stratum granulosum, and found the hyperkertosis at the 72 hrs, 120 hrs, and 168 hrs group than C group. The C group alleviated inflammation in the dermis than B group at the 24 hrs and 48 hrs. And inhibited the proliferation of the epidermis at the 72 hrs, 120 hrs, and 168 hrs groups than B group. In conclusion, Lithospermum erythrorhizon water extracts may protect the UVB-damaged mouse skin.
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KEYWORD
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CAT, SOD, Lithospermum erythrorhizon, Mouse skin
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